The aim of this study was to select, formulate and physico pharmaceutical evaluation of powder mixture of micronutrients, minerals and excipients forming a sprinkle powder dosage form intended to correct cases of stunting. Sprinkle powder mixtures were prepared by simple mixing the active pharmaceutical ingredients (APIs) with different inactive ingredients namely; lactose, sucrose, dextrose, aerosil, magnesium stearate and vanilla extract into five formulations. Formulations were characterized physically (i.e. uniformity of weight, angle of repose, tapped and bulk density, Hausner�s ratio and Carr�s index) to select the most suitable formula with optimum flowability. The selected formula was evaluated regarding its moisture content. Possible interactions between APIs and excipients were investigated using differential scanning calorimetery (DSC). Results showed that, the five formulations had acceptable weight variation ranging from (5.36 ? 0.305 g) for F3 and (4.83 ? 0.208 g) for F4. Optimum flowability (angle of repose 39.2 ? 0.6o) was attained by (F5) indicating that aerosil acted as glidant better than magnesium stearate. This result was confirmed by the bulk and tapped densities values (0.76 ? 0.04 and 0.89 ? 0.07 g/cm3 respectively) which reflected the good flow and rearrangement properties of (F5). DSC results proved the absence of chemical interactions between the different ingredients of powder mixtures.
Loading....